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It took a couple days - maybe 2-3 before we noticed a difference. I hope Prilosec works for you! I really credit the switch to Prilosec with my LOs ability to eat solid foods and get more than 2 hours of sleep at a time!

It took about 2-3 days? It was seriously life-changing when it started working! I hope it works for you too!

@Eko: For us, there was a distinct difference in that pre-Prilosec they would be up at night writhing, twisting around and screaming in pain, not able to settle down, the second we'd lay them down flat in their cribs they'd start crying. With Prilosec that all disappeared. They were older, though, (almost a year) so I had more of a baseline of what was normal. Did you try any other reflux meds prior to Prilosec? I have read conflicting info about Prilosec working on babies that young. When my LOs were that young, they were on Zantac (DD) and Prevacid (DS). DS continued to spit up a lot on Prevacid, but it was much less painful (no screaming after eating, back arching, etc.). The increase in your LO's appetite could be the Prilosec working... Maybe he's not having pain while eating now and wants to eat more? Or that and the fussiness could be related to a growth spurt, like you said. I'd give the meds some more time. Are you working with a GI or regular ped? I wish we'd started with our GI sooner!

@Eko: I'd give it a little bit more time, try to get beyond his growth spurt, then re-evaluate to see if it's working. My kids' never experienced gassiness as a side effect of reflux, so I can't speak to that much. It's possible there's another issue going on - sensitivity to dairy, or something else you're eating (if he's on breastmilk). I think that can start off with really similar symptoms to reflux in the beginning.

@Eko: DS started on Prilosec around 10 weeks, I think? Anyway, his main symptoms were pain/fussiness (back arching, etc.) during and after feedings. Feedings were a serious battle! Those symptoms completely disappeared with the proper dosage of Prilosec. He was never a great sleeper early on, so I didn't notice any correlation between the Prilosec use and sleep.

It sounds like the fussiness (as long as it's not related to eating), increased appetite, and poor sleeping may be due to a growth spurt/wonder week. I think there's a wonder week right around 8 weeks? Right around my son's 8-week wonder week (which for him was closer to 7 weeks bc they go by due date & he was 8 days late), there was a day where I literally nursed him for 5 or 6 hours total throughout the course of the day! It was absolutely miserable - he was either nursing, fussing, or fighting sleep. (It was Halloween which is why I remember so vividly!) Good luck getting through it - things will start getting better soon!