Do you have it? Do you medicate?

I have a long overdue international trip that I am potentially going on in January with my then 3 yr old and 1 yr old. It's a 15-16 hour direct flight. I've had really bad anxiety with flying as an adult but I guess not SO bad that I needed medication.

Now if I'm going to be traveling with my kids, I don't want to have panic attacks now thinking that we're ALL going to die every time there is a turbulence or weird noise (for 15-16 hours). My anxiety is so bad that I just want to chicken out of this trip all the time.