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I can't answer all your questions but wanted to bump for you and offer hugs. it's really hard to be in this situation. mine is not exactly the same, mild PCOS and unexplained repeat chemical pregnancies (both on and off meds). I've been pregnant 5 times and have 1 LO and struggling for #2 right now.
what worked for me the first time was clomid. this time, not so much. I got pregnant one clomid/IUI this time but it ended quickly. I am hoping to try femara at a new clinic and then may be looking at IVF.
my RE said he thought IVF might help because you get a little "test drive" for the days before the embryos are placed, to see which are strongest/highest quality. I have no reason to believe embryo quality is my issue but I can see his point. at the same time I am really scared we might get pregnant on IVF and have another chemical anyway. if you look up SART data for IVF at a specific clinic (all available online) you can see success rates but I don't think it breaks it down by type of issue unfortunately. the truth with unexplained issues is often just that no one knows.

sometimes this whole thing just sucks. the uncertainty of wondering if you are just wasting your time putting yourself through all the treatments. there are a lot of women on here who get it. I would encourage you to join the weekly infertility check-in if you'd like more support!

Just wanted to offer some hugs and support. I was diagnosed with unexplained infertility around 7 years ago, tried 4 unsucessful IUIs, clomid, etc and am now 29 weeks pregnant without any intervention (am also in my mid-30s). Just know that there is hope!

I don't have any experience, but my cousin has unexplained infertility, and she does have a 3yo. He was conceived naturally with no intervention, though it took several years. She's now working on using natural methods, like herbs and things, and it's looking at least somewhat positive. She's ovulating for the first time. If it winds up working out, I'll report back with what she did for those who are interested.

I can't answer your questions either, but I would suggest talking to your RE. They could give you more accurate numbers.

Also, have you thought of getting a second opinion through another clinic. We just left our last RE office because of our failed IUIs and we wanted a new set of eyes. (The real reason for leaving was because I wasn't happy with some of their policies.) The new office has had great reviews on getting people pregnant after seeing another office. I finally got hopes of a possible diagnosis. It's so good to have an possible answer. We are starting IVF soon and my new RE is hopeful that IVF will work.

I was also unexplained. I got pregnant on my 3rd iui with clomid. My DH also took vitamins recommend by the RE. I'm currently pregnant with my second which happened while NTNP. Good luck!

I can only speak to the AMH question...there are symptoms associated with DOR but not specifically low AMH. And like @Mrs Green Grass: said, I wouldn't sweat the AMH too much because that number alone doesn't predict very much. Mine was very close to undetectable when first tested and most likely became undetectable by the time I got pregnant, but my RE never felt my egg quality was an issue. There are a lot of factors that work together.

@Jenn23: Interesting! 3 years ago my AMH was 1.25 and now it is around the 2 range. My dr finds it weird that AMH is going up instead of down like it's suppose to over time. My new RE thinks it's a mild PCOS with DOR. We did a clomid challenge to confirm it. I will get to see the results from the test next week.

@mopeybuthopey: I just wanted to send you some big ((hugs)). I really like the graphic @Mrs.Someone posted because I think it makes a couple of really good points. While there are many cases that really are unexplained, my experience and that of my friends is that sometimes REs are quick to say "unexplained" and push for IVF. I personally did not feel comfortable spending the money on IVF (my insurance covers nothing) until I knew we had exhausted every other possibility. I went through a slew of tests and saw a pelvic pain specialist... and ultimately had a laparscopy that diagnosed endometriosis and 2 blocked tubes. So I am no longer unexplained, but it took us a long time to get there and I am really glad I pushed for answers (because having a diagnosis made it easier to seek the right interventions).

@mopeybuthopey: I'm in your boat, so I can't help with advice on how my pregnancy happened. I do have one child but have been trying nearly 11m for the 2nd.
It sucks because I am in the testing phase of it all. We havent done anything with the RE yet, and so we're probably "on hold" for another cycle or two. So far, they say "unexplained infertility". I am mediocre in ALL my results, so nothing good to report, yet nothing bad to report. Everything is just inconclusive. I know how it feels I am hoping the iui does work for you! But my RE was saying (since my insurance covers it), with unexplained IF, it may be better to skip it and just go straight to IVF. Mostly for the likelihood that it'll work, but also for the genetic testing.

@CupQuakeWalk: AMH just tells you so little by itself that it's not very useful. And to illustrate how infrequently it's tested and how little REs care, my second RE (who sees mostly high FSH/DOR patients) tested my FSH multiple times each cycle and never once tested my AMH.

@CupQuakeWalk:
@spaniellove:

It's funny you guys just posted this as my RE is the opposite. He thinks that the AMH is a much better predictor of DOR. Here's two sites (just did a quick google) that state that, too although they say FSH is better over 40 or 42 years old. Wonder why all the RE's have such different views about this topic! Just more to make us all scratch our heads and wonder!

http://www.centerforhumanreprod.com/anti-mullerian-hormone.html
http://www.fertilityassociates.co.nz/boosting-your-fertility/checking-your-fertility.aspx

@Jenn23: Years ago (before TTC) when I was going through the process of egg donating, I was actually denied by two clinics because of my low AMH. I found a clinic that did not use AMH. Yeah, it is interesting what REs think.

@bluestriped bee: Wait, you donated eggs? I didn't know this!

@spaniellove: I don't get what you mean? Often the AMH and FSH have a strong correlation (or whatever the right word I'm looking for is) so one is high, the other low, etc. What does that have to do with changing RE's? An RE could say that if you just had a high FSH, too, right? Not sure I follow you. My friend uses Abington and they only do FSH, not AMH and she was told the same thing. Her number was a 17 the last IVF and they mentioned donor eggs. She didn't and had her 2nd successful IVF just two years ago. So I think RE's can mention donor eggs whether is is a high FSH or low AMH?

@Jenn23: Oh not that it has anything to do with AMH/FSH, just that I think I ended up at the place for more desperate cases. But my FSH didn't correlate that well with my AMH when we started out, it didn't make sense. It was in the 8-9 range and I honestly think they just didn't know how to treat DOR. At that point I hadn't done any treatments yet and had only been TTC 6 months.

@Jenn23: Very glad they're going with current methods for your cycle!

And OP, my apologies!

@mopeybuthopey: I know, it is so expensive. I take it you have no coverage at all? We don't either. We paid all out of pocket. I hope you don't have to do it, but just know if you do, it will increase your odds greatly!!

@mopeybuthopey: Yep, that's my little IVF baby! We had no choice but IVF (only have one tube left and it is blocked) and I was also told I had DOR at the time and I wasn't optimistic. After two years of crazy procedures and surgeries I had all but given up hope. It was the most depressing time of my life for sure!!! But it worked for us!!! I actually didn't believe it until the day my son was born. It was so surreal for me. I just thought I was not meant to have a baby since everything had gone wrong for so long. So I KNOW what it feels like. It totally sucks and is so unfair!! But just know you have good odds with IVF and try to be positive and I wish you all the best. ((Hugs))