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I had a recurrent loss workup after my third early miscarriage in a row (could have been four but only 3 were confirmed). And I'd had a prior loss before my first child. I thought that my consecutive losses were possibly due to nursing (I was still nursing my 1 year old) but my doctor didn't agree and thought it was just bad luck or chromosomal (since I was 35). The work up showed that all of my numbers were normal except shockingly low AMH. Low AMH tied with high FSH is indicative of low ovarian reserve, but there's very little research about low AMH in and of itself. Some believe that it has to do with egg quality. My mother did have early menopause (age 40) and at the time of my weird results, I was 35. Based on these results we made an appt. with an RE; but then I got and stayed pregnant -- unfortunately that baby was sick with an open neural tube defect but we did not find out until 18 weeks and he was born sleeping shortly thereafter.

One thing that I did NOT ever get tested for was the MTHFR mutation (which is believed to impact the body's ability to absorb folic acid). It is really debated in the medical community whether MTHFR mutation impacts fertility or birth defects -- my OB's feeling (and same with my geneticist and high risk OB) was that it's hogwash since so many people have the mutation. Also that because I'd had two healthy children, even if I did have it, it wasn't a factor in my fertility. Ultimately I went on a super high dose of prescription folic acid and also took methylfolate (direct folate) and then got and stayed pregnant again and ended up with a healthy pregnancy and baby.

This is something you may want to look into. There are other women here who probably have more info on MTHFR than me, but I can say the internet is a bit of a rabbit hole on this issue.

So sorry for your losses

I did it and got no answers, although I guess it was helpful to rule some things out like chromosome issues or clotting etc. I only had one d&c we could test and that was a trisomy (22 maybe? One of the ones that always ends early). So we know that one was random bad luck. My RE’s perspective at the time of the testing was that for whatever reason we made more than normal amounts of genetically flawed embryos (this was after my first 3 earlier losses) - probably something they could not test for - but we also knew we’d had one healthy baby. I guess in a way it was helpful because we knew it was likely an odds game, but we might have to play a long time. He suggested IVF so we could do PGD and pick the “best” but never got there because we moved and ended up with a viable pregnancy on our own.

I’m so sorry you have to deal with this. It’s heartbreaking but I think it’s worth ruling things out in case there is a straightforward answer - even knowing there probably won’t be.

@lilyofthewest: I totally know what you mean about feeling worse if there is no answer. I am trying to hold onto the hope that there will be something they can tell us (i.e. it was just a bad embryo) rather than finding out there is a very specific reason..

I’m on my phone so I can’t type too much now, but get your progesterone tested, and clotting factors. Once I started Lovenox I got pregnant right away (and it stuck).

I did not have a "recurrent loss workup" -- not sure what that is -- but I started working with an RE at age 39.

My history prior to the RE was (1) mc at age 35 (2) my son who was born when I was 36 and (3) mc #2 at age 38. I was diagnosed with "unexplained infertility" and told that it was likely just that my egg quality was lower due to my age.

I got pregnant two more times with the RE. The first turned into mc #3 (which was in progress on my 40th birthday! fun!). Now I am 14w pregnant with twins, and I will be 41 when they are born.

They ran an analysis on mc #3 and determined that it was a trisomy 6 which is a random event (ie not hereditary/genetic) and incompatible with life.

If you have an issue such as a translocation then you can look into IVF + PGS to screen the embryo before implanting. That is expensive though!

I did the panel work up. They didn't find anything significantly off about me, but they also tested my husband at the same time and they actually found male factor issues that were concerning.

BUT I DID actually end up having a major problem, which the panel wouldn't have shown anyway. I had golf-ball sized brain tumor that was impeding my pituitary gland, so it wasn't supporting my pregnancies because I wasn't making the right amount of hormones. I had to have brain surgery to remove it and it took a year of recovery (my hormones were out of whack the entire time) and then we miraculously got pregnant twice (they told us with DH's factors alone we would need IVF).