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What about reflux? When our LO was waking up every 30 min and crying nonstop, spitting up and coughing it was caused by reflux. She also had gas and we did the drops as well. I didnt like switching formuals but we ended up trying 5 differnt ones. We ending up on a partially broken down formula that is easier on her tummy, Gerber soothe.
ETA we also had to start holding LO upright for atleast 20 minutes after feeding her, which helped a lot.

I would make an appointment right away and ask for a referral to a Ped GI Specialist. The last thing you need is for your LO to start associating eating with pain, and decide to limit her eating to reduce her pain. And it does sound a lot like reflux (my LO had it too), and I had better luck with the Ped GI than with LO's regular Ped.

@LazyLightning: LO ended up on zantac for the reflux which helped her so much! And she was on that til she was about 5 months old. She still spit up but no pain so no crying. I know you are suppose to wait 2 weeks between formulas but honestly there was a couple that we tried that she screamed so bad that we consulted with our Dr and she said it would be ok to switch sooner. We only did that twice once was after a week and once was after a day (really bad!).

Are you able to use a crib wedge or keep LO propped while sleeping if it is reflux?

@LazyLightning: it sounds very similar to my son who was milk and soy intolerant. Now at 2 he can do milk but can't digest soy. We ultimately had success with neocate formula.

@LazyLightning: my lo would do the same thing. A friend showed me how to roll up a big blanket and safety pin it to the crv wedge. It kept LO from Sliding and Rollin around. Would have never thought to do that myself!