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Yes I would definitely call doctor! I never had a reaction to ovidrel so not sure but that looks bad!

I have really bad allergies, so I have a lot of experience with hives! As long as your breathing isn't being affected, it's just uncomfortable and annoying. So there's different types of antihistamines and you can double up. For instance, benadryl and zantac are both antihistamines but they work in different ways, so you can use both at the same time. Best thing is to alternate your four hour doses. So take benadryl, 2 hours later take zantac, 2 hours later benadryl, etc. You can do some research to see the different classes of antihistamines. Also, Aveeno makes an oatmeal bath, which is temporary relief, but actually works pretty well for the inflammation and swelling. It's best in cool water. I hope you feel better soon!!!

@Weswife: I've never been on ovidrel so I'm not sure about the reaction specifically to that... But when I've had allergic reactions before, it usually lasts until the medication gets out of your system, so if you keep taking it, it keeps happening. Until your body clears it out, you can only really treat the symptoms.