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I used it for 2 weeks during an IUI cycle and only for 3 days this last cycle, but I don't recall hot flashes either time. I don't lay down for 30 minutes either, and wasn't told that was necessary. I was instructed to do 3x a day the last cycle, so laying down for 30 min at work for my afternoon insertion isn't exactly realistic either. It's not going to fall out, and there's gonna be leakage either way.

Ditto what @PurplePumps said. I used it from my transfer up til 8w, 3x/day (2x would've been nice!!). I absolutely did not lie down afterwards. That would be so difficult to work out on a practical level!

I did mine at night I think, so I was lying down, but if I did it twice I wouldn't.

I used endometrin. Never had hot flashes but had a bunch of other symptoms. I didn't lie down after. I felt like it took a long time to melt/absorb so it wasn't until hours and hours later that I saw the gross aftereffects so I don't think laying down for 30 min would have done anything.

I always start them the morning after ER, and do three times per day. I've never been told to lie down afterwards, and I've never even heard of anyone doing this. Although if you can get me a doctor-required nap for "medical reasons" in the middle of the work day, I'll take the doctor's note, please! I think they make me sleepy, and I am always hot during the stim meds and the TWW, but I don't know if both are down to the progesterone only. Are you on Estrace pills also? I definitely struggle with waking up super hot at night during stims and after.

In case anyone else stumbles across this, my nurse told me it's only because progesterone supplements can cause dizziness. It's nothing to do with effectiveness or absorption. So basically just pay attention to your reaction and if you notice it makes you dizzy, take necessary precautions including lying down.

@Sunshine1810: It is usually recommended to use Endometrin suppositories during bed time. Your attending nurse isn't wrong in asking you to lay down after taking it, to decreases the chances of the suppository slipping out and assist better drug dissolution. Also, progesterone may cause a bit of dizziness too in some patients right after administration. About the hot flushes - it's not very common. I haven't myself experienced it but have definitely heard people going through the same. It is possible that hot flushes are just a mix of all the other side-effects like dizziness, headache, constipation, icky discharge etc. It may have been happening now in second IVF cycle because of the intensity of side-effects increases on prolonged or repeated use; naturally, you're experiencing it in second cycle. I don't think there's much to worry about it.