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I started on 500 mg/day and moved up to 1500 mg/day. Regular metformin was hard on me, but my RE switched me to ER, which helped me up the dose. I never got past 750 with the regular. I only ovulated once in 6 months on metformin alone and it was at cd 41. When I upped to 1500 mg/day I also started clomid and conceived with 100mg clomid plus the metformin.

RE recommended that I stay on it during the entire pregnancy unless my OB felt strongly otherwise (she didn't). I discontinued at 1 wk postpartum because it wasn't really serving a purpose and the 1500 mg was hard on my stomach (but interestingly I had no stomach issues with it during the actual pregnancy).

@PurplePumps: My original number was within normal range, but on the high side. I don't remember specifics. I was well within normal range by the time the RE repeated the testing. But she also said it was the first line treatment for PCOS regardless when she upped me to 1500mg.

@Hoots: @DesertDreams88: How long were you on the Met before starting Clomid. My RE had told me that it wouldn't help since there is no insulin resistance, but I've been debating asking for it before my next IVF cycle anyways. As long as it can't hurt.... I'm willing to try anything.

I started it towards the end of a cycle (a couple of days after my diagnosis) and then the next cycle I tried Clomid.

@PurplePumps: It started the met about seven months before Clomid. I have lean PCOS so I'm not sure if that makes a difference.

I took metformin (1500 mg daily) leading up to and through my latest fresh IVF cycle. I do not have diagnosed PCOS or insulin resistance, but I did have previous failed cycles of IVF. So my RE recommended it for general hormone regulation (I did have ovarian hyper stimulation syndrome during my first fresh IVF cycle - my estrogen was a bit out of control). It seems to have done its job because the fresh cycle was much more controlled than the first time around.

@PurplePumps: For me, even though there was no clear cut reason for adding the metformin, my RE felt like it couldn't hurt. I did not continue on it for the FET, only during stimulation through beta for the fresh cycle.