Apologies in advance if this is all vague and long...

Today I received a recruitment email about an available position at a company in my current city, but not my current industry.
Part of me wants to brush it off. I am very happy at my job, and there are upcoming opportunities to advance at least one more level (at which point I would have gone as far as possible). This could happen for me within 5-10 years (probably closer to 5). I would need to return to school and get another degree for that to be an option (legally. not just as a company requirement), but my employer also provides tuition assistance to current employees.

The biggest factor in making me consider moving forward with this new opportunity is that I would probably make considerably more money. The work would be more stressful as I would potentially move to supervising a small laboratory (15 people) to a much larger operation (potentially 100).

I am totally intimidated even by the thought of making a change like this. I am terrified to start something new and fail spectacularly. I'm even scared to respond to the recruitment email expressing interest because (although my education is provided on my LinkedIn profile) I'm not even sure I'm qualified for this position (same situation as within my own company - there are legal requirements for degrees under certain accrediting agencies). Lots of impostor complex happening here with me.

What would you do if you were me? Stay comfortable, go back to school and move up within my own company? Reach out and see what this offer entails? I want to think there's no downside to at least speaking with the HR director and learning more, but I don't want to start this process only to fail.