DH and I live very close to family, but don't love where we live for a number of reasons, and think about moving. Still, Scribble gets to see his grandparents and great-grandparents on a weekly basis. We are never at a loss for a babysitter. I am itching to do something different and moving may be necessary, but I would be filled with guilt if we moved.
I often wonder, people who live in geographically ideal places but far from family, do you feel guilt? Is it worth it to be able to live in a place that you love for whatever reason--career, education options for your LO(s), environment, culture, etc.