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The end goal is predictable ovulation and but they do it in completely different ways. I think Clomid blocks estrogen receptors so that your produce more. Femera, if I remember what my RE told me right actually suppresses production so that it tries harder and therefore produces more once you stop taking it. Femera half live is much more than Clomid and it out of your system very quickly. Injectibles are actually the hormones you would produce yourself, rather than a mechanism to cause your body to produce more hormones on it's own. My RE said injectibles have a much higher risk of more follicles and it involves more monitoring.

If you o regularly, I doubt you would want to do injectable for an Iui because it's the hardest way to control number of embryos. It hunk it makes sense to try unmed first and then move to Clomid/femara...they are very similar.

Good luck!

@Kelli_Deluxe: I did 2 IUI's with Clomid and then my third IUI was with injectibles. And now I have a little 4 month old baby boy from our successful 3rd IUI. The difference for me with injectibles was the ability to adjust the meds as we went along. Really fine tuning the results that would show up in my monitoring. It felt like there was more control in the process. Even though it's still a dash of magic that anyone can get pregnant, I think injectibles were the best method for our success.