Does anyone else experience middle of the night puking?

Background: the first MOTN puke was when D was about 6 months. He didn't cry and we didn't find out til morning. The second and third times happened in a row so I was more worried. We took D in and he had an ear infection. Vomiting isn't a common symptom but can be one. Those two were full wake-ups with crying. Then he puked again two nights ago (8 days post meds starting). Again we didn't find out until morning. He missed one dose of amoxicillin that day, but otherwise everything was normal.

He also throws up his bedtime bottle frequently, but it's different since its all milk (not bile). He's on pediasure during the day but I only give him half ped and half formula at night in case the extra calories are making it too hard for him to handle that bottle. It's typically higher volume than the rest of the day.

Finding out your LO puked during the MOTN is so sad! I read one thing that sometimes kids throw up when they are hungry. Or it could be reflux related, or sickness.... Anyone else have a story or suggestion?