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Have you gotten retested yet? I was originally on 25mcg, and now 50. I don't feel any different, but I didn't really have any symptoms to begin with. I think it takes 4-6 weeks to really kick in.

Do you know why they had you taking them at night? I know not everyone agrees but most people take these meds in the morning, on an empty stomach, waiting 30 min to an hour before eating or drinking anything but water. Maybe that's the problem?

I had my thyroid removed because of thyroid cancer. It was a process trying to find the right dose and I remember being very frustrated because I still felt crappy. As much as it sucks to feel so bad, most doctors do want to wait a full month before upping your dose.

I felt a very subtle shift in my energy levels over the course of the 6 months it took to find the right dose. It was almost like one day I woke up and realized I didn't feel like crap and hadn't for the last few days. That's when I called my doctor and he tested me. He was comfortable with that dose so that's where it stayed.

One thing about levothyroxine is that is has kind of a long half- life so you don't notice it's affects right away. Another pointer from my endo: Always take it in the morning about an hour before eating and to not take it with your vitamins. i think it's calcium and iron that can impact your body's absorption of the hormone. Also, if you start taking the brand name drug, its important to stick with the brand. Apparently with levothyroxine/Synthroid, the supposedly "inactive" ingredients do make a difference. It's frustrating! Hope you start to feel better soon!

I've been on levothyroxine for years now after I had my thyroid fully removed in 05. When I started taking it, a few weeks after my thyroidectomy (I had TONS of T4 in my system), they tested me weekly until I got the right dose. I also had some serious thyroid issues that wrecked havoc on my system for almost a year so they were REALLY trying to get me leveled out. Being the awesome patient I am, I've gone times where I've forgotten to take it for long periods, will test, see my tsh is high, take my meds, and literally the next day my levels be normal & be feeling much better so I would definitely question still feeling bad. (It takes a long time for it to be out of your system though).

Like @PointeShoesTutus: said, it DOES matter which one you take as some can take the name brand while others can't and vise versa with the generic... it may not even be an issue of you having the wrong dose, but the wrong brand.

Having thyroid imbalances totally stink, I hope you can get your levels where they need to be soon!

I haven't noticed any real difference since taking the levothyroxine but then again, I'm pregnant, so I'm tired regardless. I'll be curious to see how taking it affects me afterward. My pharmacist told me to take it in the morning and not eat or drink anything for an hour (other than water). I often take it when I randomly wake up around 5 so that if I'm hungry when I get up I can eat. I'm surprised they told you to take it at night. I really hope you start to feel better. Could it be stress or something else causing the exhaustion?

I did not ever notice a significant difference in how I felt since starting levothyroxine. There may have been a gradual feeling better overall but I also started acupuncture and yogalates all around the same time so I can't pinpoint the thyroid meds and definitely didn't see any immediate change. Good luck, I hope you see improvement too, especially with the morning sleepiness.