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At that age I'd break the trip up (just like you plan to) and otherwise drive when baby hopefully sleeps. When we road tripped with our then 5 month old we brought a changing pad so we could do diaper changes in the car and used it for baby for lay on for a couple of minutes to get his energy out. Other than that BF on demand and sleeping in good hotels so you feel comfortable to bring baby along.

Good luck! We did a (MUCH SHORTER!) 5-hr-each-direction road trip with LO when she was three months old. It was rough. We had the car so packed with stuff that there was no room to sit next to her in the back seat and that is my regret. She was freaking out crying back there for hours on end--I'm not sure that one of us being back there for her to see and to comfort her would have totally changed that. But it couldn't have hurt. We would talk and try to soothe her by voice from the front seat but it seemed to just make her more angry that we wouldn't pick her up. At that time she had definite "witching hours" between 5-10pm. We were stupid to drive during that time. At home she screamed for that entire time period unless being bounced on a yoga ball--literally. So doing most of our 5-hr drive during that timeframe on the way down was a disaster. It was much better on the way home when we drove during the day.

We brought her bassinet (a collapsible UB Vista bassinet that packed great) and stroller base, a bunch of clothes and swaddles (we didn't have access to laundry on our trip), and almost brought the (deflated) yoga ball, but didn't. We didn't bring a baby bath or anything and it was fine. It was nice to have her bassinet that she was used to sleeping in. I was exclusively breastfeeding so that made that part easy.

At the end of the trip we both wished we had just flown because enduring her screaming for hours on end (even with regular stops to try to soothe her and make sure she was dry and not hungry - nope, just mad!) was traumatic. But she was a pretty challenging baby until she hit 4 months and magically got happier/easier/more comfortable.

Good luck! I'm sure others will have more helpful tips!

We did a road trip at 3 months, Altho it was only 5 hours, each way. DS hates the car and his car seat so we were really nervous. We only drove when it was nap time for him. We would stop when he woke up and have breakfast, and walk around with him for fresh air, then when he was ready for the next nap (2 hours later) we would drive. I would lean over and nurse him in the car, he would fall asleep and then I would crawl into the front seat so I could sit with DH. We couldn't stop the car for me to switch seats or he would wake up. We set up a little changing station in the back seat on the other side so diaper changes were quick and easy. It took us a while to drive the normal five hours, like 10 in total, but we stopped at a lot of really nice restaurants and had great meals, it's was our vacation too, right? I love the idea of leaving at bed time and driving thru the night, but DH didn't want to do it.it does mean you arrive at your destination tired.

Have the supplies you need for a stop ready: diapers,wipes, burp cloth, etc.
be prepared to hold your bladder if the baby is sleeping. Also, bring snacks and drinks for you and DH so you don't have to make a sudden stop if baby is sleeping
I learned to have a manual pump or bottle ready in case of traffic and baby screaming for food. Feed on the go!

I know it sounds scary doing it for the first time. But road trips are the easiest (for us!) when they're that young! Plan to leave around nap time, if she's good/sleeping, then keep going! When you do have to stop I would fuel up each time to elongate the next stretch. Good luck!