We've been on two flights with our now 4 month old and I actually like sitting in the back of the plane. Shorter trip to the bathroom. With twins, we take longer to get off the plane so we wait til everyone is off. Our first flight, we sat in the middle of the plane and holding a baby while juggling diapers, wipes and diaper changing wipes was sorta challenging. It was so much easier on our return flight when we were in the second to last row on the plane.