I've been working from home for a few years now, and I think the hardest part may be that it's not always easy to talk to other adults.
I have a weekly breakfast with a local friend in my industry, and I talk to Bee about work too - plus we meet up with friends for playdates, and chat about life then. But I've come to realize that talking to adults takes regular and pro-active planning. It's not like when I worked in an office, where you could just chat with random people whenever you felt like it. Or you had meetings where you could hash work stuff out with like-minded people.
Do you ever miss talking to adults?