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I took it daily and it sadly only took the edge off on good days.

The all day sickness worries me if/when I get pregnant again and wonder how people take care of their first born when they are that sick. Please let us know how that goes for you!

I take Zofran almost every day - some days it seems to work pretty well (I still have nausea, but don't actually throw up), other days it seems to do nothing at all to help.

I trust my doctor and the practice is one of the best in our state, so I don't worry about taking what she prescribes me. What I do worry more about is not getting enough of the proper vitamins and nuitrients if I am throwing up all the time - that's a greater concern to me personally than taking something that has been widely prescribed for many years. (My mom says she believes she took Zofran when she was pregnant with me, and I'm 30, so its not a new drug, if that's a concern for you).

I also was prescribed a suppository pill (fun times....) which works REALLY well, but it completely knocks me out, so obviously, I only take that at night. Sorry, I can't remember the name, but I'm sure its something your doctor would be familiar with.

Even with these meds, I am still several pounds under my prepregnany weight at almost 12 weeks along.

I took it every day for much of my first and third trimesters.

I took zofran in my first trimester and into second trimester. I still feel sick now at times but dont take it on a daily basis anymore (19 weeks.)
Like some said, it worked wonders some days and others were still rough. I would still throw up everyday... but at least the nausea was much more bareable.

I tried the Unisom B6 thing for a while, but when the m/s got to be horribly bad, I did take Zofran for about 10 days. It worked really well for the nausea and vomiting, but ended up backing me up so badly that I preferred the m/s and went back off of it. I was very sick until about week 18 and then it slowly eased off. I still feel pretty bad most nights, but nothing like how it was. I lost a lot of weight in my first tri, too, and didn't gain anything until the 5 lbs. recently (I'm 21 weeks). It WILL get better, it's just hard to not know exactly when that will be If the Zofran works for you, I say take it! It's worth it to feel like you can actually function and it's perfectly safe for baby.