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We did this when I was pregnant with DS #1. However, it was close enough that we could drive between locations, which is obviously different.
In our situation, DS, stayed at his job and commuted/worked remotely for the first 9 months, and then found a different job in our new location. While commuting wouldn't work for you, would possibly staying at your current position and working remotely be at all possible? That would make the huge transition more manageable and then once you're settled, you could maybe job hunt for something local.
As far as buying a new home, you could do the majority remotely. If you found an agent you liked and trusted, you could have them pre-screen homes with your specific criteria for you and then fly out to see the best ones, choose one and then do all the paperwork remotely. Selling your home could easily be done remotely- you would just need someone trusted (usually a lawyer, but you could also use a friend/family member) to sign a "power of attorney specifically for the sale of the house" and then they would sit in at the Closing and sign in your stead. You could also do this when buying a place, but buying/mortgages do require more paperwork/signatures than as a Seller).
While this sounds like a long and stressful list, it's all specific things you CAN do and cross off, and then your quality of life, near family with help, would be better, it sounds like. In my case, it has been very worth it- while we were in the thick of it, it was hard but manageable. Only after the fact were we like, omg that was nuts I can't believe we did it. Good luck!

My biggest piece of advice is that you probably shouldn't expect THAT much help from your family. Even if you have very firm and clear conversations and agree to terms before getting the help, people change their minds all the time. Sure, if its a matter of having someone who can babysit now and then and perhaps pick your kid up once in awhile, that's doable, but I don't think you can expect your family to do any heavy lifting.

I don't know if your husband requires disability services or government programs provided through the state, but you probably want to research that and make sure that's all straightened out. I had a friend with CP and wheelchair bound who had to move several times in 10 years and each state did things very differently and she was constantly fighting some bureaucrat about her services.

You may want to look into renting for about a year. You can hold any money from a home sale for a year before taxes kick in and it will give you a chance to get more acquainted with the area and services and also because most jurisdictions (and federal law) require reasonable accommodations for people with disabilities in rentals. For instance, when we rented, my husband had to be in a wheelchair for a few weeks following surgery and our landlord built him a temporary ramp and took it down for us when he was healed. Things like shower bars or handles or ramps would be seen a reasonable under most standards. You're not allowed to discriminate against a renter under federal law for a disability, but if you feel like you may be subject to that kind of treatment (some people are quite nice about it), you may just want to not mention the disability until after you've executed the lease and then say by the way my husband is in a wheelchair, I need a ramp. Also you may be able to rent a home that an elderly person used to live in that already has all the accessible things installed in the home. That is extremely common where DH's family lives - there are a lot of old people there who seem to like to age in place well past the point that they should and trick out their homes with all the accessible stuff, and then when they have to move into assisted living, don't give up their homes because they feel they will move back. (And as an upside, they sell for a lot less when they hit the market eventually because usually its an estate sale and they are trying to sell fast). If you're in a rental you can also try to buy in an off-season, like in the winter, and get a much better deal on movers, home prices, etc.

For us, whenever we have moved, we just decided the move needed to happen and then we had to figure out a job first. In your case, once you're done making sure your husband's needs can be met in the new location, then go deep into looking for a job, then triage housing options in relation to that job (commute, daycare, etc), and then just commit to do it. In your shoes, I'd probably focus on moving out there first and then selling the house. You can throw everything into a Pod or have movers come box it up when it comes down to it and its easier to stage and sell a house once its empty anyway.

@macintosh: Well, I hope it works out. I come from a fairly close-knit immediate family that I've always been able to rely on and similarly relied on my mom for some part-time childcare after her convincing us to for a long time. While I did not have a longterm disability to deal with, I was recovering from a brain tumor, had crippling PPA/PPD, and then found out we were surprise expecting DS2 - meaning we really needed the help. But even after setting very clear boundaries and expectations, and we were paying her mind you, we got burned really badly and we were left in a childcare lurch (where we live daycares have 18 month waitlists). It took us 9 months of chaos to find a stable childcare situation for DS1 and my relationship with my mom has never been the same again.

We have considered moving to DH's hometown. There are 3 other similarly aged grandchildren there and DH's parents are actively engaged grandparents, albeit not in daily or regular care. We would like our kids to be raised around extended family and they would definitely help us out in a pinch, but a lot of the reason we would never just up and move out there is because we'd need rock solid care and commute plans for our jobs and our children that have nothing to do with family.

@macintosh: I would love to live close to my family.

None would be caregivers in the day, but even to have another adult come over for a meal or to an event with us when my husband is working would be awesome. I can totally see why you'd want to move close and if you can, go for it. Good luck!