I know there's always talk of saving $ and getting the most use out of a LOs clothing, especially since LOs grow so darn fast! I love Brandy's (Heart & Habit) fashion posts, but it does seem MUCH easier to do this when 1st LO is a boy and 2nd LO is a girl. No one seems to bat an eye if a girl wears her brother's hand-me-downs, but what if it were the other way around? Would you dress your son in your daughter's hand-me-downs? I'm sure there are some things that can be unisex (jeans and sweatshirts namely), but would you or your SO feel weird about dressing your son in "girl's clothes"?
FWIW - I had all older boy cousin hand-me-downs forever as a kid. Not pretty in pics at all.