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It worked great for me. I took it until 22 weeks. I still felt a little yuck the first trimester but when I tried to go off it later, I felt super sick, so I stayed on it. I don't remember any side effects

@travellingbee: my dr told me to take two at night and then I could take one in the morning and one in the afternoon if needed. Only a few times did I take a morning and/or afternoon dose. The PM pills mostly did the trick for me. I don't particularly remember them making me very tired, either....I had less fatigue this time

It was a miracle worker for me. Unisom and B6 did nothing but diclegis was the bomb.

I took two at night and brought one to work in case I needed it. I think I used my day one twice. I took it until 25 weeks. I felt horrible without it. I didn't find any side effects. Maybe fatigue but I was fatigued anyway from being pregnant..it didn't make a difference.

I took two in the afternoon, one at night and one in the morning. I took it from 6w-28w. It really took the edge off and made me functional. I'd start taking it on a Friday, it makes you drowsy until you get use to it. The first few days are the hardest.

I'm still taking it at almost 29 weeks! When I first started it, it did make me sleepy during the day and that was a huge pain. And, during the first 13-14 weeks when the nausea was the worst, I would say it took the edge off, but not a miracle worker - still took Zofran as needed. (But Zofran gives me awful constipation, like bowel obstructions, so I try to avoid it)

Now, I usually take just 1 or maybe 2 pills at night and I am feeling fine. But when I try to stop taking it, I start feeling nauseous on and off again. Not like the first tri, but just icky. When I take it, I don't feel icky. I told my OB I feel totally guilty still taking it now and she said don't, it's totally safe so take it if it helps! It doesn't make me sleepy during the day anymore, either.

That was one of the first drugs they gave me. Worked for a few days but then I threw up after taking it and decided I needed something different. Though, I ended up going to the hospital for HG at 8 & 12 weeks. I'm at 21 weeks and I'm still taking anti-nausea meds.

@travellingbee Don't worry too much about being a wuss. If your nausea is keeping you from going about your day normally, and the meds help, you're better off on them.

@wheres_c: I'm on it and have been for about 3 weeks. I started with 2 at night and the first week was really hard. My nausea was better but I felt so exhausted all the time. Then after a week, it was like "poof!" and fatigue was gone. The next week was awesome, I felt almost like normal for the whole day except in the evenings, when the nausea would come back. Then I noticed the nausea creeping in again during the day so I added one pill in the morning. I can't tell if it's helped because I've been feeling worse for the last few days. I think it's probably just my morning sickness peaking though. I'm about 10.5 weeks now and have a week or two supply left and I'm hoping I won't have to refill.

ETA: Even with the nausea creeping back in, I still feel worlds better than in previous pregnancies.

@wheres_c: I took it while I was on strong antibiotic's and it helped me so much! I was a lot sicker this time, but with the antibiotic's I was waking up in the middle of the night with severe nausea and I ended up throwing up my dinner once. Once I got on Diclegis, My nausea stopped or was down to a tolerable level (i.e. I didn't feel like dying).

I tried unisom and b6 and i didn't do much but I did take unisom at night to help sleep better. I tried some zofran but it didn't do anything really. I tried phenergan and that worked the best. I just happened to have had zofran and phenergan on hand from a terrible stomach flu the month before I got pregnant. My OB told me I could take them if I wanted. I wasn't throwing up much but I had nausea all day or most of the day. I didn't take it everyday, but I took maybe one or two a week when I was feeling really bad.

I did but it made me sleep like 16 hours and I couldn't handle that so I went to b6 3x/ day and zofran before super important stuff. And I made sure I was always close to the exit/bathroom
I also has lemon ginger tea on me at all times

Worked great for me. I wouldn't have survived without it.

I had no side effects and was on it until 32 weeks. I had tried, unsuccessfully, to wean off of it 3 times prior and was unable to. So, yea, I was on it almost my entire pregnancy and it worked for me.

@marley: I felt like that the first few days too. If you can handle it, try it for a week. It took about that long for my body to get used to it. These days, I'm still tired but no worse than before I started taking it.

@catlady: @Anagram: I've read about people getting used to it. It hit me so hard that I'm scared to take it again. I'm still super dizzy and drowsy this morning and actually called in sick. I wonder if I'm just super sensitive to medication.

@marley: you might be. I'm not super sensitive, so I just felt super tired but able to stay awake.

Miracle worker for me. With my first I had HG, which lasted until the day I delivered. But on Diclegis I could just take two at night and then I would almost never vomit, and the nausea was bearable. I was prescribed Zofran but didn't take it due to the insane constipation side effects, and the Diclegis made life bearable so I also didn't feel like adding another drug to the mix with less of a long track record of safety (Diclegis has 30+ years of safety data in North America and Europe - my mom took it while pregnant with me and my sibs in the 70s!). Also, a great Canadian study showed no effect at all on kids' IQs whose moms took Diclegis (aka Diclectin in Canada): http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038813/
(fascinatingly, morning sickness was associated with higher IQ, and correlated to the severity of the morning sickness, if that's any comfort!)

The only side effect I experienced from Diclegis (again, I took two at night only) was difficulty waking up early for work and a bit of grogginess until about 10am. I never took it during the day because it made me too sleepy and the night dose alone staved off the vomiting mostly and definitely made the nausea bearable. I took Diclegis with my last pregnancy until the day I delivered--kept trying to go off it and would promptly spend the next day vomiting every time I tried that.

This pregnancy I am having a boy (sometimes associated with less severe morning sickness) and I didn't have HG, and also this time my morning sickness actually went away by 22 weeks! So I stopped Diclegis then. I had a devil of a time getting my insurance to cover it this time, which was incredible frustrating. So I paid for it out of pocket (it is $$$$!) - that shows you what a miracle it is for me! Eventually my insurance conceded but now I have to get them to reimburse me for my out of pocket purchases. GRR...

In any case, good luck to everyone dealing with morning sickness! It is so rough, but take comfort in that study that shows it can lead to smart babies!

They tried to prescribe that to me and AFTER insurance it was $400 for a month's supply! I had to turn it down. Then my doctor's office hem hawed around about getting me something else. I never did get any meds. Luckily I finally got my MS under control around week 16. Lol