My pregnancy nurse called and told me after my iffy u/s yesterday that my betas are okay but now my progesterone and estrogen have completely dropped, even though I'm on Endometrin 3x a day. So I went in for a PIO injection today and am switching to a different suppository and adding Estrace.
Has anyone ever been in a situation like this where their levels dropped and supplementing (or supplementing more) helped? I'm trying to avoid the evils of Google.
pomelo / 5228 posts
No advice, but thinking of you and hoping that everything works out OK!
watermelon / 14206 posts
Hugs and prayers for you! I don't know about any of that, but I hope it works out for you!
honeydew / 7916 posts
Thanks! The injection and Estrace so far must be doing something because I've had a migraine for days that was just like a pre-AF migraine from dropping hormones...it freaked me out because I thought something might be wrong and it's finally starting to feel better without any painkillers.
wonderful olive / 19353 posts
Sending you positive thoughts, and the new meds boost those numbers up!
nectarine / 2433 posts
@spaniellove: No experience with any of this but hopefully it is just a blip and the new combo will work for you. I think the fact that your migraine went away is great!
pomelo / 5000 posts
Hi SpanielLove--no experience with that here, but I'll be watching for updates and will be thinking of you!
coconut / 8681 posts
@spaniellove: I've been in that exact situation with both of my most recent pregnancies (one resulting in a now 6 month old LO and currently 8.5 weeks pregnant). The first time I was on P suppositories starting right after O. My progesterone still dropped to the point where I had heavy spotting. My doctor put me on PIO injections along with suppositories and only then did it slowly rise. With my current pregnancy I got pregnant by surprise so I started suppositories as soon as I found out but a week later my P was down to 9.4 (very very low) and I started spotting. I started PIO injections 2 days later and as of yesterday (2 weeks after the initial bloodtest that gave me the 9.4 number) my P is up to 30.6!!
With my first 2 pregnancies (both miscarriages) I was only on suppositories. We never moved on to PIO soooo in my experience the PIO has made the difference. And I do one shot of 2ML every 3 days. I take 2 suppositories vaginally every night as well. Feel free to ask if you have any questions! Good luck 
honeydew / 7916 posts
@Running Elley: I'm so glad you found this thread because I remembered parts of your story but couldn't remember who it was. I started suppositories a few days before I found out I was pregnant and at that point my P4 was 15...it got up to 33, then 37, so I don't know how it dropped to 10 yesterday. After a lot of back and forth I'm adding Prometrium by mouth 3 times a day in addition to the Endometrin 3 times a day and they'll check it again Tuesday. The nurse didn't like the idea of doing PIO regularly and I told her seriously I'd do anything!
coconut / 8681 posts
@spaniellove: That is quite a drop! I know that my doctor has told me that its normal for the levels to dip but this drop seems bigger than a normal fluctuation. I'm glad that they're keeping an eye on it and planning to check again! Are you on 100mg or 200mg suppositories? It sounds like your doctor definitely has a plan to keep it under control so that's good! I'd just keep an eye out for spotting as a preventative measure. For me personally I start spotting almost as soon as my P drops below 10. That's usually my warning sign that I need more supplementation. As long as you aren't spotting your P hasn't dropped too too low. I know how nerve wracking it is between P checks so I hope that you're able to have relative peace... Just know no spotting=not super super low levels= today you are pregnant= yay
coconut / 8681 posts
@spaniellove: Oh also, the fact that your HCG levels are rising appropriately is a GREAT sign! With my MCs my progesterone wasn't high enough at the beginning to get a good, solid implantation and my HCG never got really high. With my successful pregnancies (well, one for sure successful and one so far) they did rise well. That's a big victory!
pomelo / 5073 posts
No advice, but wishing you lots of happy thoughts and rising numbers!!!!
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