First of course, you clean up your LO and change their clothes. But then it's say, 11:11 pm and you have a tired kid who is wide awake but maybe still has the same cough that caused them to throw up.
Do you change the sheets and try and put them back to bed right away (in their crib, or perhaps somewhere else)? If there's some vomit in their hair, do you give them a bath? Or do you wait a while, and then put the LO back down after they're feeling better?
This is all completely hypothetical of course.