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I was nauseous until about 20 weeks with E and at around 14 weeks I also noticed that I had really bad acid reflux that made the nausea worse. I was only able to stop the diclegis at 20 weeks after I had been on prevacid for about a month. I then stayed on the prevacid until I delivered, if I missed any I was back to being super nauseous. I'm sorry you are dealing with this.

Ugh it’s awful. I second looking into acid reflux. Mine started to get bad in first tri this past pregnancy and I could hardly eat at all with it. But it wasn’t really clear that that’s what it was, until the medicine helped so much and took it back to more regular nausea. It felt more like just stomach pain and made me throw up more. Prevacid was the one that worked for me also. I took it with #2 and #3 almost the whole pregnancy, but just had regular heartburn (not awful) with #1. One of those things that got worse each time. My MS also lasted longer each time but was better by 16-18w. I hope you are feeling better soon!

@periwinklebee: just check with your doctor which they prefer for pregnancy. Mine preferred prevacid.

It is so discouraging to not feel any relief in the second trimester. I was so sick just about up to the third trimester with each of my pregnancies, and it felt so depressing as it went on. I did end up reluctantly taking something stronger with my first pregnancy. I tried to take it as little as possible, but it did let me feel vaguely human every so often. With my second baby, I stuck with a combination of B6/unisom, which I think is basically like diclegis, and muddled through. I also took an antacid religiously from about 10 weeks on, and if I missed a dose, I noticed the vomiting was worse...so maybe there was something to that. It might not hurt to try? So sorry you're going through this!